For clinicians & laboratories

From clinical question
to molecular report.

Epicheck supports test selection, coordinates sample transfer and laboratory analysis, arranges report delivery and involves specialists in interpretation.

Discuss testing

Select by clinical purpose

Find a test or sample

Clinical purpose	Testing approach	Sample type
Multiple genetic targets relevant to treatment	Targeted DNA and/or RNA NGS panel	FFPE tumour tissue; plasma only for a validated plasma assay
A broader view of tumour genomic changes	Comprehensive genomic profiling (CGP)	FFPE tumour tissue
BRCA1/2 changes in the tumour	Tumour BRCA1/2 testing	FFPE tumour tissue
Inherited BRCA1/2 changes	Germline BRCA1/2 testing	Blood
A specific mutation, including a resistance-associated variant	Real-time PCR / digital PCR	FFPE tumour tissue

Before ordering, confirm the genes and alterations examined, RNA-based fusion analysis and any validated TMB, MSI or HRD assessments. Plasma is used only for specifically validated tests.

Know what the test covers

Beyond the panel name.
The right test for the clinical question.

Molecular tests differ in the genes and genetic changes they assess. Selecting a test means matching its coverage and sample requirements to the clinical question.

DNA / RNA

DNA and RNA analysis

Check the genes, regions and types of genetic change included in the selected test. If gene fusions involving ALK, ROS1, RET or NTRK1/2/3 are relevant, confirm the assay’s fusion coverage and whether RNA analysis is included.

TMB · MSI · HRD

TMB, MSI and HRD

Tumour mutational burden (TMB), microsatellite instability (MSI) and homologous recombination deficiency (HRD) require specifically validated assessments. They are not included in every genomic panel. Confirm their availability and sample requirements before ordering.

PCR / NGS

Testing after treatment progression

Include the previous treatment regimen and timing and pattern of progression. A focused PCR test or broader NGS panel is selected according to the clinical question, previous molecular results and available sample.

A referral starts with three details.

Clinical context

Provide the diagnosis, disease stage, previous treatment and the question relevant to further management.

Sample & accompanying documents

Tell us what sample is available and provide the histology report for tumour tissue. We supply preparation, submission and transport instructions for the selected test.

Testing arrangements

Confirm analytical coverage, informed-consent requirements, performing laboratory, cost, expected reporting time and the clinician receiving the report.

Talk to Epicheck

Start with
your question.

Tell us the test you need or the clinical question you want to address. We will help clarify the analysis, specimen, cost and expected reporting time.

Contact the team